Basic Information

Symbol
SLC16A7
RNA class
mRNA
Alias
Solute Carrier Family 16 Member 7 MCT2 Solute Carrier Family 16 (Monocarboxylate Transporter), Member 7 Monocarboxylate Transporter 2 Solute Carrier Family 16, Member 7 (Monocarboxylic Acid Transporter 2) Solute Carrier Family 16 (Monocarboxylic Acid Transporters), Member 7 MCT 2
Location (GRCh38)
12:59596027-59789855
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001270623.2
Sequence length
11936.0 nt
GC content
0.3379

Transcripts

ID Sequence Length GC content
NM_001270622.2 NCBI
GCUCCUCCGCACCCACAAGGGCGUUCAGCAGCCGCGCCUCCCCUUCCCG… 11916 nt 0.3379
NM_001270623.2 NCBI
GCUCCUCCGCACCCACAAGGGCGUUCAGCAGCCGCGCCUCCCCUUCCCG… 11936 nt 0.3379
NM_004731.5 NCBI
ACAAGGAAACUUCUGCCUCAGGUGGGGAGAGGAGUCCAUAGAUCAGGGA… 11730 nt 0.3330
Summary

This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Forensic Context

A study in mice demonstrated that chronic alcohol exposure significantly upregulated the SLC16A7 mRNA in hippocampal tissue, as identified through high-throughput sequencing and bioinformatic network analysis [Du et al. DOI:10.3389/Fphar.2024.1377501].