Basic Information

Symbol
SLC17A7
RNA class
mRNA
Alias
Solute Carrier Family 17 Member 7 VGLUT1 BNPI Vesicular Glutamate Transporter 1 Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 7 Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 7 Brain-Specific Na(+)-Dependent Inorganic Phosphate Cotransporter Brain-Specific Na-Dependent Inorganic Phosphate Cotransporter VGluT1
Location (GRCh38)
19:49429399-49443197
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_020309.4
Sequence length
2949.0 nt
GC content
0.5771

Transcripts

ID Sequence Length GC content
NM_020309.4 NCBI
ACUUGCAGCCUCCUUCCCCCCGAGCGGAGCUGCGGGGCCGGCCGGGCCG… 2949 nt 0.5771
Summary

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human postmortem brain tissue identified the SLC17A7 as a protein-coding transcript and cortical marker enriched in the dorsolateral prefrontal cortex of unaffected comparison subjects [Seney et al. DOI:10.1016/j.biopsych.2021.06.007].