Basic Information

Symbol
SLC17A8
RNA class
mRNA
Alias
Solute Carrier Family 17 Member 8 VGLUT3 Vesicular Glutamate Transporter 3 Solute Carrier Family 17 (Sodium-Dependent Inorganic Phosphate Cotransporter), Member 8 Solute Carrier Family 17 (Vesicular Glutamate Transporter), Member 8 DFNA25 Deafness, Autosomal Dominant 25 VGluT3
Location (GRCh38)
12:100356842-100422055
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_139319.3
Sequence length
3984.0 nt
GC content
0.4066

Transcripts

ID Sequence Length GC content
NM_001145288.2 NCBI
AGUCUGAGAGUGGCUGCCUGAGACAGCUGCCACAGGCUGCUGCAGAGCG… 3834 nt 0.4082
NM_139319.3 NCBI
AGUCUGAGAGUGGCUGCCUGAGACAGCUGCCACAGGCUGCUGCAGAGCG… 3984 nt 0.4066
Summary

This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Forensic Context

A study in Wistar rats demonstrated that the SLC17A8 exhibited region-specific expression changes in the brain following alcohol exposure and withdrawal, with a significant decrease in the prefrontal cortex during the alcoholic condition but an increase during withdrawal, while its expression was significantly increased in the hippocampus under both conditions [Sinirlioglu et al. DOI: 10.14715/Cmb/2017.63.2.7]. A study in Wistar rats demonstrated that the SLC17A8 mRNA expression was significantly altered in specific brain regions following ethanol exposure and withdrawal, with expression decreasing in the prefrontal cortex during the alcoholic condition but increasing during withdrawal and increasing significantly in the hippocampus under both alcoholic and withdrawal conditions [Sinirlioglu et al. DOI:10.14715/Cmb/2017.63.2.7].