Basic Information

Symbol
SLC1A2
RNA class
mRNA
Alias
Solute Carrier Family 1 Member 2 EAAT2 GLT1 Excitatory Amino Acid Transporter 2 GLT-1 HBGT Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 2 Sodium-Dependent Glutamate/Aspartate Transporter 2 Glutamate/Aspartate Transporter II Human Brain Glutamate Transporter Glutamate Transporter-1 Excitotoxic Amino Acid Transporter 2 EIEE41 DEE41
Location (GRCh38)
11:35251205-35420063
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004171.4
Sequence length
12006.0 nt
GC content
0.4167

Transcripts

ID Sequence Length GC content
NM_001195728.3 NCBI
AGAGAUUUAUUCGAGCUUCGGCGGGGGAGGGAGCGCAGCUGGGCCGCGU… 11639 nt 0.4051
NM_001252652.2 NCBI
AGAGAUUUAUUCGAGCUUCGGCGGGGGAGGGAGCGCAGCUGGGCCGCGU… 11704 nt 0.4050
NM_004171.4 NCBI
GGGUGAUGUCAGCUCUCGACGAAAAUAGAGAGGGAUCGCCUGCAAAUCC… 12006 nt 0.4167
Summary

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]

Forensic Context

A study in mice demonstrated that the SLC1A2 was identified as a differentially wired gene in the prefrontal cortex of lines selectively bred for high versus low methamphetamine intake, implicating it in the transcriptomic basis of addiction risk [Hitzemann et al. DOI:10.3390/brainsci9070155]. In human bioinformatics research, the SLC1A2 served as a marker for manual annotation of astrocyte clusters in single-nucleus RNA sequencing analysis of Alzheimer's disease datasets [Weiqi Xue et al. DOI:10.3233/JAD-230559].