Basic Information

Symbol
SLC1A3
RNA class
mRNA
Alias
Solute Carrier Family 1 Member 3 GLAST-1 GLAST1 EAAT1 GLAST Excitatory Amino Acid Transporter 1 EA6 Solute Carrier Family 1 (Glial High Affinity Glutamate Transporter), Member 3 Sodium-Dependent Glutamate/Aspartate Transporter 1 Glutamate/Aspartate Transporter 1
Location (GRCh38)
5:36596588-36688335
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004172.5
Sequence length
3919.0 nt
GC content
0.4356

Transcripts

ID Sequence Length GC content
NM_001166695.3 NCBI
AGAGCACAUGCACACUGUCAGGGCUAGCCUGCCUGCUUACGCGCGCUGC… 3784 nt 0.4302
NM_001166696.3 NCBI
AGAGCACAUGCACACUGUCAGGGCUAGCCUGCCUGCUUACGCGCGCUGC… 1101 nt 0.3915
NM_001289939.2 NCBI
AGAGCACAUGCACACUGUCAGGGCUAGCCUGCCUGCUUACGCGCGCUGC… 3781 nt 0.4345
NM_001289940.2 NCBI
AGAGCACAUGCACACUGUCAGGGCUAGCCUGCCUGCUUACGCGCGCUGC… 3583 nt 0.4326
NM_004172.5 NCBI
AGAGCACAUGCACACUGUCAGGGCUAGCCUGCCUGCUUACGCGCGCUGC… 3919 nt 0.4356
Summary

This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]

Forensic Context

A study in humans undergoing cardiac surgery with cardiopulmonary bypass demonstrated that acute left ventricular ischemia induces significant changes in miRNA and mRNA expression [Saddic et al. DOI:10.1152/physiolgenomics.00049.2015]. Among the findings, the mRNA for the SLC1A3 (SLC1A3), which functions in amino acid transport, was identified as a predicted and anticorrelated target (Pearson r = -0.72) of the upregulated miRNA miR-483-3p, with this miRNA-mRNA pair emerging from integrated sequencing analysis of postischemic myocardial tissue.