Basic Information

Symbol
SLC22A7
RNA class
mRNA
Alias
Solute Carrier Family 22 Member 7 OAT2 NLT Solute Carrier Family 22 (Organic Anion Transporter), Member 7 Organic Anion Transporter 2 Novel Liver Transporter HOAT2 Organic Anion Transporter 11 Liver-Specific Transporter HOAT11
Location (GRCh38)
6:43295694-43305543
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_153320.2
Sequence length
2559.0 nt
GC content
0.5877

Transcripts

ID Sequence Length GC content
NM_006672.3 NCBI
ACUCCCACCUCCAGAGUCCAAGGGUCUAUGUGGUGGGCAGUUUGAGCUG… 2553 nt 0.5875
NM_153320.2 NCBI
ACUCCCACCUCCAGAGUCCAAGGGUCUAUGUGGUGGGCAGUUUGAGCUG… 2559 nt 0.5877
Summary

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Forensic Context

A study in the Oncopig Cancer Model (Sus scrofa) demonstrated that alcohol-induced liver fibrosis significantly alters the expression of numerous genes, including the SLC22A7 which was differentially expressed in fibrotic livers and is involved in the transport of anticancer drugs such as 5-FU, paclitaxel, and methotrexate [Yasmin et al. DOI:10.1016/J.Biochi.2020.12.022].