Basic Information

Symbol
SLC25A13
RNA class
mRNA
Alias
Solute Carrier Family 25 Member 13 ARALAR2 Calcium-Binding Mitochondrial Carrier Protein Aralar2 Mitochondrial Aspartate Glutamate Carrier 2 CITRIN Electrogenic Aspartate/Glutamate Antiporter SLC25A13, Mitochondrial Solute Carrier Family 25 (Aspartate/Glutamate Carrier), Member 13 Citrullinemia Type II ARALAR-Related Gene 2 CTLN2 Solute Carrier Family 25, Member 13 (Citrin) Citrin NICCD
Location (GRCh38)
7:96120218-96322147
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014251.3
Sequence length
3141.0 nt
GC content
0.4435

Transcripts

ID Sequence Length GC content
NM_001160210.2 NCBI
AGGCAGGCCAGGAACGCACGCUGCCUGGCCGUAUCGCCGCCCCCACCGC… 3144 nt 0.4437
NM_014251.3 NCBI
AGGCAGGCCAGGAACGCACGCUGCCUGGCCGUAUCGCCGCCCCCACCGC… 3141 nt 0.4435
Summary

This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Forensic Context

A study in mice demonstrated that the SLC25A13 transcript, a calcium-binding mitochondrial carrier protein, increased in abundance within 0.5 hours postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267]. This transcript, categorized as a transport gene, was part of a broader finding where 1063 gene transcripts showed significant, time-dependent increases after death, suggesting a step-wise shutdown process with potential for postmortem interval estimation.