Basic Information

Symbol
SLC25A37
RNA class
mRNA
Alias
Solute Carrier Family 25 Member 37 MSCP MFRN Mitochondrial Solute Carrier Protein Mitochondrial Iron Transporter 1 Mitoferrin-1 MFRN1 HT015 Solute Carrier Family 25 (Mitochondrial Iron Transporter), Member 37 Mitoferrin Solute Carrier Family 25, Member 37 Predicted Protein Of HQ2217 PRO1278 PRO1584 PRO2217 MSC
Location (GRCh38)
8:23528956-23575463
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016612.4
Sequence length
4672.0 nt
GC content
0.4942

Transcripts

ID Sequence Length GC content
NM_001317812.2 NCBI
CUCCCUGCCCACCUCCUGCAGCCUCCUGCGCCCCGCCGAGCUGGCGGAU… 5149 nt 0.4871
NM_001317813.2 NCBI
CUCCCUGCCCACCUCCUGCAGCCUCCUGCGCCCCGCCGAGCUGGCGGAU… 4796 nt 0.4954
NM_001317814.2 NCBI
CUCCCUGCCCACCUCCUGCAGCCUCCUGCGCCCCGCCGAGCUGGCGGAU… 4743 nt 0.4942
NM_016612.4 NCBI
CUCCCUGCCCACCUCCUGCAGCCUCCUGCGCCCCGCCGAGCUGGCGGAU… 4672 nt 0.4942
Summary

SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]

Forensic Context

A study in humans demonstrated that the SLC25A37 is significantly upregulated in blood samples from acute myocardial infarction patients and is a mitochondria-related hub gene with diagnostic potential, showing an individual AUC of 0.786 and being positively correlated with activated mast cells, eosinophils, and neutrophils [Xu et al. DOI:10.1097/MD.0000000000045611]. In a separate human trauma cohort, the SLC25A37 was identified as one of 16 overlapping transcripts in a blood-based prediction model for multiple organ failure, where it is implicated in iron transport and was upregulated early after traumatic injury [Duran et al. DOI:10.1186/s13613-024-01364-5].