Basic Information

Symbol
SLC26A4
RNA class
mRNA
Alias
Solute Carrier Family 26 Member 4 PDS Pendrin Solute Carrier Family 26 (Anion Exchanger), Member 4 Sodium-Independent Chloride/Iodide Transporter DFNB4 Solute Carrier Family 26, Member 4 Deafness, Autosomal Recessive 4 Pendred Syndrome TDH2B EVA
Location (GRCh38)
7:107660594-107717809
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000441.2
Sequence length
4737.0 nt
GC content
0.4036

Transcripts

ID Sequence Length GC content
NM_000441.2 NCBI
AUUCCGGGCGGGGCGCGAGCAGAGACAGGUCAUGGCAGCGCCAGGCGGC… 4737 nt 0.4036
Summary

Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]

Forensic Context

A study in zebrafish demonstrated that the SLC26A4 transcript, a solute carrier family 26 anion exchanger member 4, increased in relative abundance within 0.3 hours postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267].