Basic Information

Symbol
SLC27A5
RNA class
mRNA
Alias
Solute Carrier Family 27 Member 5 VLCS-H2 VLACSR VLCSH2 FACVL3 ACSVL6 FATP5 ACSB Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 3 Solute Carrier Family 27 (Fatty Acid Transporter), Member 5 Very Long-Chain Acyl-CoA Synthetase-Related Protein Very Long-Chain Acyl-CoA Synthetase Homolog 2 Long-Chain Fatty Acid Transport Protein 5 Long-Chain-Fatty-Acid--CoA Ligase Fatty Acid Transport Protein 5 Bile Acyl-CoA Synthetase Bile Acid-CoA Ligase Cholate--CoA Ligase BA-CoA Ligase VLACS-Related FLJ22987 FATP-5 BACS BAL EC 6.2.1.7 EC 6.2.1.3 EC 6.2.1.-
Location (GRCh38)
19:58479512-58512413
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012254.3
Sequence length
2292.0 nt
GC content
0.6265

Transcripts

ID Sequence Length GC content
NM_001321196.2 NCBI
ACUCCACAGCUGCUGCUCCUAGGGAGGAGCUGGUACCAUGGGUGUCAGG… 2040 nt 0.6176
NM_012254.3 NCBI
ACUCCACAGCUGCUGCUCCUAGGGAGGAGCUGGUACCAUGGGUGUCAGG… 2292 nt 0.6265
Summary

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

Forensic Context

A study in Apoe-/- mice demonstrated that cigarette smoke exposure induced significant proteomic alterations in the liver, including the downregulation of the SLC27A5, which is involved in bile acid metabolism [Lo Sasso et al. DOI:10.3109/08958378.2016.1150368]. These molecular changes, part of a broader dysregulation in lipid and xenobiotic metabolism networks, were substantially reduced in mice switched to a candidate modified risk tobacco product or after cessation.