Basic Information

Symbol
SLC34A2
RNA class
mRNA
Alias
Solute Carrier Family 34 Member 2 Sodium-Dependent Phosphate Transport Protein 2B NAPI-IIb NAPI-3B NaPi-2b NPTIIb NaPi2b Solute Carrier Family 34 (Type II Sodium/Phosphate Cotransporter), Member 2 Solute Carrier Family 34 (Sodium Phosphate), Member 2 Sodium/Phosphate Cotransporter 2B Type II Sodium-Dependent Phosphate Transporter 3b Na(+)-Dependent Phosphate Cotransporter 2B Sodium-Phosphate Transport Protein 2B Na(+)/Pi Cotransporter 2B NaPi3b PULAM
Location (GRCh38)
4:25648011-25679132
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006424.3
Sequence length
4115.0 nt
GC content
0.5196

Transcripts

ID Sequence Length GC content
NM_001177998.2 NCBI
GGCCGCCGCCUCCAGCCCAGCACCUGCGGAGGGAGCGCUGACCAUGGCU… 4112 nt 0.5195
NM_001177999.2 NCBI
AGUUUGUUUCUAUUAGGGCCCGUGGCCAUCAGCGAAGGGUCCGUCCUUC… 4173 nt 0.5169
NM_006424.3 NCBI
GGCCGCCGCCUCCAGCCCAGCACCUGCGGAGGGAGCGCUGACCAUGGCU… 4115 nt 0.5196
Summary

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Forensic Context

A study in humans developed a targeted RNA sequencing assay for organ tissue identification, where the SLC34A2 was expressed in kidney tissue with an average read count of 16,085 [Hanson & Ballantyne 10.3390/genes8110319]. A study in mice demonstrated that the SLC34A2 exhibited differential expression patterns depending on the radiation type and target cell, with under-expression observed specifically after Kupffer cell-specific α-particle exposure and over-expression after endothelial cell-specific α-particle, neutron, and γ-ray exposures [Roudkenar et al. DOI:10.1269/jrr.07078].