Basic Information

Symbol
SLC34A3
RNA class
mRNA
Alias
Solute Carrier Family 34 Member 3 NaPi-2c NPT2C Sodium-Dependent Phosphate Transport Protein 2C NPTIIc Solute Carrier Family 34 (Type II Sodium/Phosphate Cotransporter), Member 3 Solute Carrier Family 34 (Sodium Phosphate), Member 3 Sodium/Inorganic Phosphate Cotransporter IIC Na(+)-Dependent Phosphate Cotransporter 2C Sodium-Phosphate Transport Protein 2C Na(+)/Pi Cotransporter 2C FLJ38680 Sodium/Phosphate Cotransporter 2C Type IIc Na+/Pi Cotransporter NPTIIC HHRH
Location (GRCh38)
9:137230757-137236555
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001177316.2
Sequence length
2016.0 nt
GC content
0.6597

Transcripts

ID Sequence Length GC content
NM_001177316.2 NCBI
GUCUCCUCCCUGCAGGUGCCCCCUCACCACCCACACAGAUCUAGACCUG… 2016 nt 0.6597
NM_001177317.2 NCBI
AUGGAGACAAGGCCUAGGGGCCUUGGGGCCAGGAGGGUACCCCCGUGAG… 2163 nt 0.6574
NM_080877.3 NCBI
ACACAGGUAGGAGCUCCUAGGACCAGGCUGAGGCCCAGGGACAGUGAGG… 2125 nt 0.6602
Summary

This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.[provided by RefSeq, Apr 2010]

Forensic Context

A study in humans demonstrated that a targeted RNA sequencing assay using a panel of 46 mRNA biomarkers, including the SLC34A3, can definitively identify the source of 10 different organ and tissue types with high specificity and sensitivity [Hanson & Ballantyne DOI:10.3390/genes8110319].