Basic Information

Symbol
SLC37A4
RNA class
mRNA
Alias
Solute Carrier Family 37 Member 4 G6PT Glucose-6-Phosphate Exchanger SLC37A4 GSD1b GSD1c GSD1d G6PT1 SPX4 Solute Carrier Family 37 (Glucose-6-Phosphate Transporter), Member 4 Glucose-6-Phosphatase, Transport (Glucose-6-Phosphate) Protein 1 Transformation-Related Gene 19 Protein Sugar-Phosphate Exchange Protein 4 Glucose-6-Phosphatase Transporter Glucose-5-Phosphate Transporter Glucose-6-Phosphate Translocase TRG-19 G6PT2 G6PT3 Glucose-6-Phosphatase, Transport (Phosphate/Pyrophosphate) Protein 2 Glucose-6-Phosphatase, Transport (Glucose) Protein 3 Microsomal Glucose-6-Phosphate Transporter PRO0685 CDG2W TRG19
Location (GRCh38)
11:119023751-119030906
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001467.6
Sequence length
2312.0 nt
GC content
0.5420

Transcripts

ID Sequence Length GC content
NM_001164277.2 NCBI
GUCCUAUUCGGGCUCCCGCCUCUGUUCAGUUCCAGAGACAAUUCAUGGG… 2816 nt 0.5710
NM_001164278.2 NCBI
GUCCUAUUCGGGCUCCCGCCUCUGUUCAGUUCCAGAGACAAUUCAUGGG… 2566 nt 0.5511
NM_001164279.2 NCBI
GUCCUAUUCGGGCUCCCGCCUCUGUUCAGGACACUGGGUCCCCUUGGAG… 2242 nt 0.5482
NM_001164280.2 NCBI
GAGGGAGCAGAAAAAACCCAACUCAGCAGAUCUGGGAACUGUGAGAGCG… 2199 nt 0.5384
NM_001467.6 NCBI
GUCCUAUUCGGGCUCCCGCCUCUGUUCAGGACACUGGGUCCCCUUGGAG… 2312 nt 0.5420
Summary

This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]

Forensic Context

A study in mice demonstrated that in vivo α-particle irradiation of Kupffer or endothelial liver cells via boron neutron capture induced a characteristic inflammatory gene expression profile, with the SLC37A4 being under-expressed in Kupffer cell, endothelial cell, and neutron exposures [Roudkenar et al. DOI:10.1269/jrr.07078]. In a separate mouse model of hind limb burn injury, the SLC37A4 was also found to be down-regulated in skeletal muscle at three days post-burn, as part of a broader suppression of genes involved in glucose transport and mitochondrial energy metabolism [Padfield et al. DOI:10.01211102].