Basic Information

Symbol
SLC39A14
RNA class
mRNA
Alias
Solute Carrier Family 39 Member 14 ZIP14 Metal Cation Symporter ZIP14 KIAA0062 ZIP-14 NET34 Solute Carrier Family 39 (Metal Ion Transporter), Member 14 Solute Carrier Family 39 (Zinc Transporter), Member 14 LIV-1 Subfamily Of ZIP Zinc Transporter 4 Zrt- And Irt-Like Protein 14 Zinc Transporter 14 LZT-Hs4 Zrt-, Irt-Like Protein 14 ZRT/IRT-Like Protein 14 Zinc Transporter ZIP14 HMNDYT2 Cig19 HCIN
Location (GRCh38)
8:22366727-22434129
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001128431.4
Sequence length
4663.0 nt
GC content
0.4757

Transcripts

ID Sequence Length GC content
NM_001128431.4 NCBI
GCCCGGACGCAGUGAGGGGGGUCGGCGCGCGUGUCUACGCGGACGCACC… 4663 nt 0.4757
NM_001135153.3 NCBI
ACACGCCCGGACGGCUGGGUGGAGGCUGCACCUGGCCGUGGUGCCGCGC… 4732 nt 0.4780
NM_001135154.3 NCBI
GCCCGGACGCAGUGAGGGGGGUCGGCGCGCGUGUCUACGCGGACGCACC… 1717 nt 0.5510
NM_001351655.2 NCBI
GCCCGGACGCAGUGAGGGGGGUCGGCGCGCGUGUCUACGCGGACGCACC… 4781 nt 0.4777
NM_001351656.2 NCBI
GCCCGGACGCAGUGAGGGGGGUCGGCGCGCGUGUCUACGCGGACGCACC… 4869 nt 0.4796
NM_001351657.2 NCBI
GCCCGGACGCAGUGAGGGGGGUCGGCGCGCGUGUCUACGCGGACGCACC… 4960 nt 0.4819
NM_001351658.2 NCBI
GCCCGGACGCAGUGAGGGGGGUCGGCGCGCGUGUCUACGCGGACGCACC… 4842 nt 0.4800
NM_001351659.2 NCBI
ACUCCGCGCUCAGCGUGGGGCUAAAUAAGCCAUUCCCUGUUUGUCUGUG… 4929 nt 0.4737
NM_001351660.2 NCBI
ACUCCGCGCUCAGCGUGGGGCUAAAUAAGCCAUUCCCUGUUUGUCUGUG… 5116 nt 0.4775
NM_015359.6 NCBI
GCCCGGACGCAGUGAGGGGGGUCGGCGCGCGUGUCUACGCGGACGCACC… 4663 nt 0.4744
Summary

This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia. [provided by RefSeq, May 2017]

Forensic Context

A study in mice demonstrated that the SLC39A14 was acutely upregulated in the corpus callosum-external capsule at 2 days post-traumatic brain injury, where it was identified as a uniquely differentially expressed gene in that region [Kounelis-Wuillaume et al. DOI:10.1177/08977151251390528].