Basic Information

Symbol
SLC39A8
RNA class
mRNA
Alias
Solute Carrier Family 39 Member 8 BIGM103 ZIP-8 ZIP8 Metal Cation Symporter ZIP8 BCG-Induced Integral Membrane Protein In Monocyte Clone 103 Protein Solute Carrier Family 39 (Metal Ion Transporter), Member 8 LIV-1 Subfamily Of ZIP Zinc Transporter 6 Zrt- And Irt-Like Protein 8 ZRT/IRT-Like Protein 8 Zinc Transporter ZIP8 LZT-Hs6 BCG-Induced Integral Membrane Protein In Monocyte Clone 103 Solute Carrier Family 39 (Zinc Transporter), Member 8 BCG Induced Integral Membrane Protein BIGM103 Zinc Transporter 8 PP3105 CDG2N
Location (GRCh38)
4:102251080-102431258
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001135146.2
Sequence length
3152.0 nt
GC content
0.4296

Transcripts

ID Sequence Length GC content
NM_001135146.2 NCBI
GAGUUUCACCGCGGACCUGUCAGAGAUACAGAGGUUGUGGGGGCGGGAG… 3152 nt 0.4296
NM_001135147.1 NCBI
GACUCCGGAAGAGCCCUUUUCUGCAGCUCCUUGGGGACUGCACGUCUCA… 4098 nt 0.4480
NM_001135148.2 NCBI
AGCGAUUCUCCUGCCUCAGCCUUCCGAGUAGCUGGGAUUACAGGCAUGC… 2605 nt 0.3747
NM_022154.5 NCBI
GGCGGAGAGAAUAAAGCAGAAAGACAGGAAGAGGAGGUGGAGUUCUACA… 3309 nt 0.4346
Summary

This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

Forensic Context

A study in humans identified a molecular signature of chronic cocaine abuse in postmortem midbrain dopamine neurons, with the SLC39A8 transcript upregulated 1.6-fold in cocaine abusers and performing as a diagnostic classifier in subject assignment [Bannon et al. DOI:10.1038/Npp.2014.70].