Basic Information

Symbol
SLC41A3
RNA class
mRNA
Alias
Solute Carrier Family 41 Member 3 FLJ20473 Solute Carrier Family 41, Member 3 SLC41A1-Like 2 SLC41A1-L2
Location (GRCh38)
3:126005662-126101561
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_017836.4
Sequence length
2182.0 nt
GC content
0.5486

Transcripts

ID Sequence Length GC content
NM_001008485.2 NCBI
CUCUUUCCCGCCGCCGCCUGGGAGGGGACCCGGGCUGCCAGGCGCCCAG… 1633 nt 0.5579
NM_001008486.2 NCBI
CUCUUUCCCGCCGCCGCCUGGGAGGGGACCCGGGCUGCCAGGCGCCCAG… 1525 nt 0.5567
NM_001008487.2 NCBI
GAGGUCUGUAGAGCUGGCCUGAGGAGGCAGUCCCUCUGUGCUGAUCUCU… 2618 nt 0.5527
NM_001164475.2 NCBI
AGUCACGCUGGAGACCUCUGGUGCAGAUGGGCGAGACUGGACCCAGCUU… 1942 nt 0.5294
NM_017836.4 NCBI
CUCUUUCCCGCCGCCGCCUGGGAGGGGACCCGGGCUGCCAGGCGCCCAG… 2182 nt 0.5486
Summary

Enables magnesium:sodium antiporter activity. Involved in mitochondrial magnesium ion transmembrane transport. Located in mitochondrial inner membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that peripheral blood gene expression signatures, including the SLC41A3 (SLC41A3), can diagnose partial body radiation exposure, with a signature for hind limb irradiation across 0.5, 2, and 10 Gy doses predicting radiation status versus non-irradiated controls with 79-100% accuracy [Meadows et al. DOI:10.1371/journal.pone.0011535]. In human research, the SLC41A3 was also identified as a single-gene biomarker capable of differentiating methamphetamine dependents with psychosis from those without in a machine-learning classifier achieving 95% accuracy [Breen et al. DOI:10.1038/tp.2016.67].