Basic Information

Symbol
SLC43A2
RNA class
mRNA
Alias
Solute Carrier Family 43 Member 2 Solute Carrier Family 43 (Amino Acid System L Transporter), Member 2 Large Neutral Amino Acids Transporter Small Subunit 4 L-Type Amino Acid Transporter 4 MGC34680 LAT4
Location (GRCh38)
17:1569268-1630103
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_152346.3
Sequence length
8133.0 nt
GC content
0.5854

Transcripts

ID Sequence Length GC content
NM_001284498.2 NCBI
AGGUCUGGGCGCUGAUCUUGUGGUUGAAGAAACCAGCUCUGGGGAAGGG… 8440 nt 0.5883
NM_001284499.1 NCBI
AGCAAAGCUGGUCCUUCCCCUCCUGGGGUCCUUCCCCUCCGCCAGCCCU… 7872 nt 0.5835
NM_001321364.2 NCBI
AAAAGGCGCCGGGCGGGCCCGACACACGCCGGAGGAGCCGGGUGGUGCA… 8145 nt 0.5855
NM_001321365.2 NCBI
AGGUCUGGGCGCUGAUCUUGUGGUUGAAGAAACCAGCUCUGGGGAAGGG… 8407 nt 0.5875
NM_152346.3 NCBI
AAAAGGCGCCGGGCGGGCCCGACACACGCCGGAGGAGCCGGGUGGUGCA… 8133 nt 0.5854
Summary

This gene encodes a member of the L-amino acid transporter-3 or SLC43 family of transporters. The encoded protein mediates sodium-, chloride-, and pH-independent transport of L-isomers of neutral amino acids, including leucine, phenylalanine, valine and methionine. This protein may contribute to the transfer of amino acids across the placental membrane to the fetus. [provided by RefSeq, Mar 2016]

Forensic Context

A study in rhesus macaques identified the SLC43A2 as a shared upregulated differentially expressed gene in left ventricular tissue between adult human and rhesus macaque hypertrophic cardiomyopathy [Rivas et al. DOI:10.1038/s41598-024-82770-4].