Basic Information

Symbol
SLC44A4
RNA class
mRNA
Alias
Solute Carrier Family 44 Member 4 NG22 CTL4 C6orf29 DFNA72 TPPT Thiamine Pyrophosphate Transporter 1 Choline Transporter-Like Protein 4 FLJ14491 HTPPT1 Chromosome 6 Open Reading Frame 29 Solute Carrier Family 44, Member 4 Testicular Tissue Protein Li 48 TPPT1
Location (GRCh38)
6:31863192-31879198
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_025257.3
Sequence length
2585.0 nt
GC content
0.5497

Transcripts

ID Sequence Length GC content
NM_001178044.2 NCBI
ACUCCGGAGACUGAGCCAUGGGGGGAAAGCAGCGGGACGAGGAUGACGA… 2459 nt 0.5523
NM_001178045.2 NCBI
ACUGAGGUCCCACCAGAGUGAGGAUGUACAGGGCCGCUUCCCUCCCCAG… 2637 nt 0.5491
NM_025257.3 NCBI
ACUCCGGAGACUGAGCCAUGGGGGGAAAGCAGCGGGACGAGGAUGACGA… 2585 nt 0.5497
Summary

The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Forensic Context

A study in human prostate tissue demonstrated that the long non-coding RNA ENST00000479777, which is associated with the gene SLC44A4, was significantly upregulated in samples with a high postmortem interval (PMI) compared to those with a low PMI [Javan et al. DOI:10.1038/s41598-025-29561-7].