Basic Information

Symbol
SLC4A4
RNA class
mRNA
Alias
Solute Carrier Family 4 Member 4 KNBC1 NBC1 Electrogenic Sodium Bicarbonate Cotransporter 1 HNBC1 HhNMC NBCe1 NBC2 PNBC KNBC Solute Carrier Family 4 (Sodium Bicarbonate Cotransporter), Member 4 Pancreatic Sodium Bicarbonate Cotransporter Kidney Type Na+/HCO3- Cotransporter Na(+)/HCO3(-) Cotransporter SLC4A5 Sodium Bicarbonate Cotransporter 1 (Sodium Bicarbonate Cotransporter, Kidney; Sodium Bicarbonate Cotransporter, Pancreas) Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4, Brain Type Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 5 Sodium Bicarbonate Cotransporter NBCe1-A PRTAO NBCE1 NBC
Location (GRCh38)
4:71062667-71572087
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001098484.3
Sequence length
7716.0 nt
GC content
0.3990

Transcripts

ID Sequence Length GC content
NM_001098484.3 NCBI
GGCGGCGCGCCGGGCAGCGCUUCGGUGGCGGCGGCGGCCGCGGUGGCAG… 7716 nt 0.3990
NM_001134742.2 NCBI
GGCACAGCCUCCGCCGCGGCCGCCUUCCGUGAGCCCCCGCACCCCGGCU… 8113 nt 0.4174
NM_003759.4 NCBI
GUCUUAUAAUUUUGGAUGAGUCAUAAGUGGAGAAGGAGGGGAAGUGAGU… 7669 nt 0.3929
Summary

This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Forensic Context

A study in rats demonstrated that the SLC4A4 is an orthologous gene associated with inflammatory processes in radiation-induced lung injury, as identified through single-cell transcriptomic analysis [Shi et al. DOI:10.17305/bb.2024.10357].