Basic Information

Symbol
SLC4A8
RNA class
mRNA
Alias
Solute Carrier Family 4 Member 8 NBC3 Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 8 Electroneutral Sodium Bicarbonate Exchanger 1 Electroneutral Na(+)-Driven Cl-HCO3 Exchanger K-NBC3 KIAA0739 NDCBE1 NDCBE NBC
Location (GRCh38)
12:51391317-51515763
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001039960.3
Sequence length
11764.0 nt
GC content
0.4614

Transcripts

ID Sequence Length GC content
NM_001039960.3 NCBI
GCGGGCCGGUGGCUAUGGAGGCGGCGGCGGUUGAUGGUUGACCGUUGGC… 11764 nt 0.4614
NM_001258401.3 NCBI
AGUGAGGAGGAAGAGGAAGAGGCGAAGGCUGGCGGAGGAGGAGAGACCA… 11602 nt 0.4579
NM_001258402.2 NCBI
GCGGGCCGGUGGCUAUGGAGGCGGCGGCGGUUGAUGGUUGACCGUUGGC… 2297 nt 0.5067
NM_001258403.2 NCBI
CCCGAGCCCAGGCUUCCCAGGCCGCUCCCUGAGGGCGAGGGGAGGCCAG… 3038 nt 0.4987
NM_001267615.2 NCBI
AGUGAGGAGGAAGAGGAAGAGGCGAAGGCUGGCGGAGGAGGAGAGACCA… 2135 nt 0.4909
NM_001405266.1 NCBI
AGUGAGGAGGAAGAGGAAGAGGCGAAGGCUGGCGGAGGAGGAGAGACCA… 2783 nt 0.4783
NM_001405268.1 NCBI
GCGGGCCGGUGGCUAUGGAGGCGGCGGCGGUUGAUGGUUGACCGUUGGC… 11350 nt 0.4602
NM_001405270.1 NCBI
AGUGAGGAGGAAGAGGAAGAGGCGAAGGCUGGCGGAGGAGGAGAGACCA… 11621 nt 0.4579
Summary

The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Forensic Context

A study in humans characterized the platelet transcriptome in patients with acute myocardial infarction and identified the SLC4A8 as having increased expression in platelets from ST-segment elevation MI (STEMI) patients compared to non-STEMI patients [Eicher et al. DOI:10.3109/09537104.2015.1083543].