Basic Information

Symbol
SLC6A12
RNA class
mRNA
Alias
Solute Carrier Family 6 Member 12 BGT-1 Solute Carrier Family 6 (Neurotransmitter Transporter, Betaine/GABA), Member 12 Solute Carrier Family 6 (Neurotransmitter Transporter), Member 12 Sodium- And Chloride-Dependent Betaine Transporter Na(+)/Cl(-) Betaine/GABA Transporter Betaine/GABA Transporter-1 BGT1 Gamma-Aminobutyric Acid Transporter GAT2
Location (GRCh38)
12:190069-220144
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001122848.3
Sequence length
3210.0 nt
GC content
0.5561

Transcripts

ID Sequence Length GC content
NM_001122847.3 NCBI
AGCUCAGUGAUUAGCCUGUGGAGCAGGAAAGUCCAGCGAUGGGCAGCUG… 3166 nt 0.5550
NM_001122848.3 NCBI
ACACACAGCCCCCGCCCCAACACAUACACACACGGCUUCUUUCUGUCUG… 3210 nt 0.5561
NM_001206931.2 NCBI
ACACACAGCCCCCGCCCCAACACAUACACACACGGCUUCUUUCUGUCUG… 3125 nt 0.5574
NM_003044.5 NCBI
AGCUCAGUGAUUAGCCUGUGGAGCAGGAAAGUCCAGCGAUGGGCAGCUG… 3751 nt 0.5596
Summary

Enables gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in gamma-aminobutyric acid transport and monocarboxylic acid transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in cell projection and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the SLC6A12 mRNA was significantly upregulated in ante-mortem burned skin compared to controls, identifying it as a potential biomarker for vital reaction [Liu et al. DOI:10.1007/s12024-022-00474-5]; however, subsequent validation in human autopsy specimens showed its expression did not change significantly in burned human skin [Liu et al. DOI:10.1007/s12024-022-00474-5]. In a separate investigation in rats, the SLC6A12 was significantly upregulated in striatal microglia/macrophages at 2 hours and 3 days following a binge methamphetamine regimen [Kays & Yamamoto DOI:10.3390/brainsci9120340].