Basic Information

Symbol
SLC6A15
RNA class
mRNA
Alias
Solute Carrier Family 6 Member 15 NTT73 SBAT1 Hv7-3 V7-3 Sodium/Chloride Dependent Neurotransmitter Transporter Homo Sapiens Orphan Neurotransmitter Transporter NTT7 Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 15 Solute Carrier Family 6 (Neurotransmitter Transporter), Member 15 Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT73 Sodium-Dependent Neutral Amino Acid Transporter B(0)AT2 Sodium-Coupled Branched-Chain Amino-Acid Transporter 1 Homolog Of Rat Orphan Transporter V7-3 Transporter V7-3 FLJ10316 Orphan Sodium- And Chloride-Dependent Neurotransmitter Transporter NTT73 Orphan Transporter V7-3 B0AT2
Location (GRCh38)
12:84859491-84913629
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_182767.6
Sequence length
4799.0 nt
GC content
0.3755

Transcripts

ID Sequence Length GC content
NM_001146335.3 NCBI
AUACGCAUGUACACGCGCACCCGCACCCGCGCGCCUGUAUCCCGUGCUG… 4322 nt 0.3755
NM_018057.7 NCBI
AUACGCAUGUACACGCGCACCCGCACCCGCGCGCCUGUAUCCCGUGCUG… 4232 nt 0.3629
NM_182767.6 NCBI
AUACGCAUGUACACGCGCACCCGCACCCGCGCGCCUGUAUCCCGUGCUG… 4799 nt 0.3755
Summary

This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Forensic Context

A study in mice selectively bred for high and low ethanol preference from HS-CC founders demonstrated that selection markedly affected the expression and network connectivity of numerous genes in the nucleus accumbens shell, including the SLC6A15 which was identified as a splicing hub node directly associated with alcohol-related phenotypes [Colville et al. DOI:10.1111/Gbb.12367].