Basic Information

Symbol
SLC6A2
RNA class
mRNA
Alias
Solute Carrier Family 6 Member 2 NET Norepinephrine Transporter SLC6A5 NAT1 NET1 Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2 Solute Carrier Family 6 (Neurotransmitter Transporter), Member 2 Sodium-Dependent Noradrenaline Transporter Solute Carrier Family 6 Member 5 Neurotransmitter Transporter
Location (GRCh38)
16:55655988-55707645
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001172501.3
Sequence length
5933.0 nt
GC content
0.5026

Transcripts

ID Sequence Length GC content
NM_001043.3 NCBI
GUCAGAAGUCUCCAACUCUUGAGUUCCGGCGUGCCCCAACCUCUGUUUC… 3551 nt 0.5393
NM_001172501.3 NCBI
ACGGCCAGAACCAGUCAGCCCGCGCCCUGCCGGCCGCCCCGCGCCUCCA… 5933 nt 0.5026
NM_001172502.1 NCBI
AGGUUGUGUGCUCCUUAUGAGAAUCUAACUAACGCCUGAUGACCUGAGG… 3157 nt 0.5220
NM_001172504.1 NCBI
AGCCUCGGCGUGCCCCCAGGACCGGUAAAGUUCCUCUCGCCAGCCGCAU… 2858 nt 0.5140
Summary

This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Forensic Context

A study in mice demonstrated that prenatal exposure to psychostimulants like amphetamine, cocaine, and methamphetamine permanently impaired glucose homeostasis in adult female offspring by reducing insulin production in pancreatic beta cells, an effect linked to disrupted serotonin signaling and sex-specific epigenetic reprogramming [Korchynska et al. DOI:10.15252/embj.2018100882].