Basic Information

Symbol
SLC7A1
RNA class
mRNA
Alias
Solute Carrier Family 7 Member 1 CAT-1 REC1L HCAT1 ATRC1 ERR Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 1 High Affinity Cationic Amino Acid Transporter 1 Ecotropic Retroviral Leukemia Receptor Homolog System Y+ Basic Amino Acid Transporter Ecotropic Retrovirus Receptor Homolog Amino Acid Transporter, Cationic 1 Ecotropic Retroviral Receptor CAT1
Location (GRCh38)
13:29509410-29595781
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003045.5
Sequence length
7343.0 nt
GC content
0.5274

Transcripts

ID Sequence Length GC content
NM_003045.5 NCBI
GCACUGCUGAUGAAACCUGGCGCCGGAACCCGCCAGCCCUCGGCGCCCA… 7343 nt 0.5274
Summary

Enables L-arginine transmembrane transporter activity; L-histidine transmembrane transporter activity; and L-lysine transmembrane transporter activity. Involved in carboxylic acid transport. Located in apical plasma membrane and basolateral plasma membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in rats demonstrated that the SLC7A1 was identified as an orthologous gene associated with inflammatory processes in a single-cell transcriptomic analysis of radiation-induced lung injury [Shi et al. DOI:10.17305/bb.2024.10357]. In rhesus macaques, transcriptomic profiling of hypertrophic cardiomyopathy identified the SLC7A1 as a shared upregulated differentially expressed gene between affected macaques and pediatric human HCM cases [Rivas et al. DOI:10.1038/s41598-024-82770-4].