Basic Information

Symbol
SLC7A2
RNA class
mRNA
Alias
Solute Carrier Family 7 Member 2 SLC7A2A SLC7A2B CAT-2A CAT-2B CAT-2 HCAT2 ATRC2 Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 2 Low Affinity Cationic Amino Acid Transporter 2 Cationic Amino Acid Transporter 2 CAT2
Location (GRCh38)
8:17496975-17570573
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001370338.1
Sequence length
7615.0 nt
GC content
0.4144

Transcripts

ID Sequence Length GC content
NM_001008539.4 NCBI
CUCCUUCUGCAGCGCGGCCGGCGGGCGCUCCUCUUCGCGGGACCAGCGA… 7569 nt 0.4137
NM_001164771.2 NCBI
UCCCAAAACAGAAAGAGCAGAUGUCUCACCACGAAACUAGCAACUGGAA… 7565 nt 0.4066
NM_001370337.1 NCBI
CUCCUUCUGCAGCGCGGCCGGCGGGCGCUCCUCUUCGCGGGACCAGCGA… 7612 nt 0.4158
NM_001370338.1 NCBI
CUCCUUCUGCAGCGCGGCCGGCGGGCGCUCCUCUUCGCGGGACCAGCGA… 7615 nt 0.4144
NM_003046.6 NCBI
UCCCAAAACAGAAAGAGCAGAUGUCUCACCACGAAACUAGCAACUGGAA… 7562 nt 0.4080
Summary

The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Forensic Context

A study in rats demonstrated that the SLC7A2 is an orthologous gene associated with inflammatory processes in radiation-induced lung injury [Shi et al. DOI:10.17305/bb.2024.10357]. In rhesus macaques, the SLC7A2 was identified as a shared upregulated differentially expressed gene between affected animals and pediatric human patients with hypertrophic cardiomyopathy [Rivas et al. DOI:10.1038/s41598-024-82770-4].