Basic Information

Symbol
SLC7A7
RNA class
mRNA
Alias
Solute Carrier Family 7 Member 7 Y+LAT-1 Y+LAT1 Y+L Amino Acid Transporter 1 Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7 Lysinuric Protein Intolerance (Dibasicaminoaciduria II) Y(+)L-Type Amino Acid Transporter 1 Monocyte Amino Acid Permease 2 MOP-2 LPI Solute Carrier Family 7 (Cationic Amino Acid Transporter, Y+ System), Member 7 LAT3
Location (GRCh38)
14:22773222-22829820
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003982.4
Sequence length
2082.0 nt
GC content
0.4995

Transcripts

ID Sequence Length GC content
NM_001126105.3 NCBI
GUCACACUGUGCAACCUUCCUCCCUUUCUUAAAUGCUUGGGGCAUUUGU… 2139 nt 0.4993
NM_001126106.4 NCBI
AGUCCCCGUUACCCUCUGCUUUUUCUGCUCCUCAGAGUCAACAGCUGUU… 2252 nt 0.5049
NM_003982.4 NCBI
CCCUUUUACUGCUGGCUGGGAAGGAGGAGCAUCAGACCACAGAUCCUGG… 2082 nt 0.4995
Summary

The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

Forensic Context

A study in the Oncopig (Sus scrofa) model of alcohol-induced liver fibrosis demonstrated that the SLC7A7 was differentially expressed in fibrotic livers compared to controls, as part of a broader transcriptional reprogramming involving altered expression of SLC transporter genes involved in the transport of anticancer drugs like activicin [Yasmin et al. DOI:10.1016/J.Biochi.2020.12.022]. A study in Wistar rats demonstrated that the SLC7A7 was significantly increased in the corpus striatum under both alcohol-addicted and withdrawal conditions compared to controls [Sinirlioglu et al. DOI: 10.14715/Cmb/2017.63.2.7].