Basic Information

Symbol
SLIT1
RNA class
mRNA
Alias
Slit Guidance Ligand 1 Slit-1 MEGF4 SLIT3 SLIL1 Multiple Epidermal Growth Factor-Like Domains Protein 4 Multiple EGF-Like Domains Protein 4 Multiple EGF Like Domains 4 Slit Homolog 1 Protein Slit (Drosophila) Homolog 1 Slit Homolog 1 (Drosophila) Slit Homolog 1 KIAA0813
Location (GRCh38)
10:96998038-97185959
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003061.3
Sequence length
7964.0 nt
GC content
0.5940

Transcripts

ID Sequence Length GC content
NM_003061.3 NCBI
CUCCUCGCAGCAGUCAGUUGGGAGCUGGAGGGAGGGAGAGGGAGACGCA… 7964 nt 0.5940
Summary

Enables Roundabout binding activity. Involved in axon extension involved in axon guidance; motor neuron axon guidance; and negative chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice and humans demonstrated that the SLIT1 is predominantly expressed in the atrial cardiomyocyte cluster aCM2, which is associated with metabolic regulation of cardiomyocytes in the right atrium following myocardial infarction [Bian et al. DOI:10.3892/mmr.2025.13680].