Basic Information

Symbol
SLIT3
RNA class
mRNA
Alias
Slit Guidance Ligand 3 Slit-3 MEGF5 Slit2 SLIT1 SLIL2 Multiple Epidermal Growth Factor-Like Domains Protein 5 Multiple EGF-Like Domains Protein 5 Multiple EGF Like Domains 5 Slit Homolog 3 Protein Slit (Drosophila) Homolog 3 Slit Homolog 3 (Drosophila) Slit Homolog 3 KIAA0814
Location (GRCh38)
5:168661740-169301139
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003062.4
Sequence length
9716.0 nt
GC content
0.5389

Transcripts

ID Sequence Length GC content
NM_001271946.2 NCBI
ACUGAAUGGAGAGAGCGAGCGCCGGCCAGCUCACCCGGCCGCCCCGUGC… 9737 nt 0.5389
NM_003062.4 NCBI
ACUGAAUGGAGAGAGCGAGCGCCGGCCAGCUCACCCGGCCGCCCCGUGC… 9716 nt 0.5389
Summary

The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Forensic Context

A study in mice demonstrated that the SLIT3 is predominantly expressed in the atrial cardiomyocyte cluster aCM2, which is associated with the metabolic regulation of cardiomyocytes in the right atrium [Bian et al. DOI:10.3892/mmr.2025.13680].