Basic Information

Symbol
SLITRK2
RNA class
mRNA
Alias
SLIT And NTRK Like Family Member 2 CXorf2 KIAA1854 SLITL1 SLIT And NTRK-Like Protein 2 Transmembrane Protein 257 TMEM257 CXorf1 SLIT And NTRK-Like Family, Member 2 Chromosome X Open Reading Frame 1 Slit-Like 1 (Drosophila) Slit And Trk Like Gene 2 Slit-Like 1 XLID111
Location (GRCh38)
X:145817819-145829856
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032539.5
Sequence length
8421.0 nt
GC content
0.4072

Transcripts

ID Sequence Length GC content
NM_001144003.3 NCBI
CUCCUUCCUGCAAGAAGCGUUGCCCGUUGGCUAGCUGCUCGGUGGGGAU… 7938 nt 0.3956
NM_001144004.3 NCBI
CUCCUUCCUGCAAGAAGCGUUGCCCGUUGGCUAGCUGCUCGGUGGGGAU… 3912 nt 0.4599
NM_001144005.3 NCBI
CUCCUUCCUGCAAGAAGCGUUGCCCGUUGGCUAGCUGCUCGGUGGGGAU… 7948 nt 0.3957
NM_001144006.2 NCBI
GUUGGAGGUGGAGUAGUUCAGAAUCAACUGACGCAGCCGGGAAUUGAGC… 4154 nt 0.4615
NM_001144008.2 NCBI
GUUGGAGGUGGAGUAGUUCAGAAUCAACUGACGCAGCCGGGAAUUGAGC… 4166 nt 0.4616
NM_001144009.2 NCBI
GUUGGAGGUGGAGUAGUUCAGAAUCAACUGACGCAGCCGGGAAUUGAGC… 4007 nt 0.4570
NM_001144010.2 NCBI
GUUGGAGGUGGAGUAGUUCAGAAUCAACUGACGCAGCCGGGAAUUGAGC… 4144 nt 0.4614
NM_032539.5 NCBI
CUCCUUCCUGCAAGAAGCGUUGCCCGUUGGCUAGCUGCUCGGUGGGGAU… 8421 nt 0.4072
Summary

This gene encodes an integral membrane protein that contains two N-terminal leucine-rich repeats domains and contains C-terminal regions similar to neurotrophin receptors. The encoded protein may play a role in modulating neurite activity. Alternatively spliced transcript variants encoding the same protein have been described.[provided by RefSeq, Feb 2010]

Forensic Context

A study in mice demonstrated that fetal alcohol exposure (FAE) induces long-lasting alterations in adult brain DNA methylation and non-coding RNA expression, with the SLITRK2 being downregulated (-1.20-fold) in the voluntary consumption model and identified as a crucial target deregulated by specific miRNAs [Laufer et al. DOI:10.1242/Dmm.010975].