Basic Information

Symbol
SLMAP
RNA class
mRNA
Alias
Sarcolemma Associated Protein SLAP KIAA1601 Sarcolemmal Membrane-Associated Protein Sarcolemmal-Associated Protein
Location (GRCh38)
3:57755450-57931461
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001377540.1
Sequence length
6381.0 nt
GC content
0.4227

Transcripts

ID Sequence Length GC content
NM_001304420.3 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6240 nt 0.4223
NM_001304421.2 NCBI
CGGCCGCGAUCUCAAACCAAACACAAGAAUUGGCGUGUGACUCAUCUGC… 5409 nt 0.3805
NM_001304422.3 NCBI
AGUUUGGGCUUGGAUGGUAACGUUUAUUUUCCUUGGCAGAGAAGCUGAU… 3892 nt 0.3569
NM_001304423.3 NCBI
AGUUUGGGCUUGGAUGGUAACGUUUAUUUUCCUUGGCAGAGAAGCUGAU… 3694 nt 0.3549
NM_001311178.2 NCBI
AGUUUGGGCUUGGAUGGUAACGUUUAUUUUCCUUGGCAGAGAAGCUGAU… 3982 nt 0.3599
NM_001377538.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6312 nt 0.4211
NM_001377539.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6291 nt 0.4217
NM_001377540.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6381 nt 0.4227
NM_001377541.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6330 nt 0.4232
NM_001377542.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6330 nt 0.4227
Showing 1 to 10 of 26 entries
Summary

This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Forensic Context

A study in human heart tissue from sudden unexplained death (SUD) cases identified the SLMAP as a differentially expressed cardiac-related gene, with mutations in this gene reported in ion channelopathies or cardiomyopathies [Neubauer et al. DOI:10.1007/S00414-025-03414-4].