Basic Information

Symbol
SLMAP
RNA class
mRNA
Alias
Sarcolemma Associated Protein SLAP KIAA1601 Sarcolemmal Membrane-Associated Protein Sarcolemmal-Associated Protein
Location (GRCh38)
3:57755450-57931461
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001377540.1
Sequence length
6381.0 nt
GC content
0.4227

Transcripts

ID Sequence Length GC content
NM_001377545.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6318 nt 0.4226
NM_001377549.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6279 nt 0.4233
NM_001377551.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6177 nt 0.4222
NM_001377552.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6267 nt 0.4232
NM_001377555.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6258 nt 0.4228
NM_001377557.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6126 nt 0.4223
NM_001377559.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6216 nt 0.4233
NM_001377562.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6207 nt 0.4234
NM_001377921.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6207 nt 0.4229
NM_001377922.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6195 nt 0.4228
Showing 11 to 20 of 26 entries
Summary

This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Forensic Context

A study in human heart tissue from sudden unexplained death (SUD) cases identified the SLMAP as a differentially expressed cardiac-related gene, with mutations in this gene reported in ion channelopathies or cardiomyopathies [Neubauer et al. DOI:10.1007/S00414-025-03414-4].