Basic Information

Symbol
SLMAP
RNA class
mRNA
Alias
Sarcolemma Associated Protein SLAP KIAA1601 Sarcolemmal Membrane-Associated Protein Sarcolemmal-Associated Protein
Location (GRCh38)
3:57755450-57931461
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001377540.1
Sequence length
6381.0 nt
GC content
0.4227

Transcripts

ID Sequence Length GC content
NM_001377923.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6156 nt 0.4235
NM_001377924.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6144 nt 0.4233
NM_001377925.1 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6093 nt 0.4234
NM_001377926.1 NCBI
AGUUUGGGCUUGGAUGGUAACGUUUAUUUUCCUUGGCAGAGAAGCUGAU… 3769 nt 0.3550
NM_001377927.1 NCBI
AGUUUGGGCUUGGAUGGUAACGUUUAUUUUCCUUGGCAGAGAAGCUGAU… 3859 nt 0.3581
NM_007159.5 NCBI
AGUCAGAGUCACUAUGGCGGCCGGCGCUGGCAAGGUCGGAAAGUUUCCU… 6189 nt 0.4224
Showing 21 to 26 of 26 entries
Summary

This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Forensic Context

A study in human heart tissue from sudden unexplained death (SUD) cases identified the SLMAP as a differentially expressed cardiac-related gene, with mutations in this gene reported in ion channelopathies or cardiomyopathies [Neubauer et al. DOI:10.1007/S00414-025-03414-4].