Basic Information

Symbol
SLN
RNA class
mRNA
Alias
Sarcolipin MGC125854 MGC125855 MGC12301
Location (GRCh38)
11:107707375-107719696
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003063.3
Sequence length
722.0 nt
GC content
0.4820

Transcripts

ID Sequence Length GC content
NM_003063.3 NCBI
AGACAGCCUGGGAGGGGAGAAGGAGUUGGAGCUCAAGUUGGAGACAGCG… 722 nt 0.4820
Summary

Sarcoplasmic reticulum Ca(2+)-ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca(2+) from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca(2+)-ATPases. The transmembrane protein interacts with Ca(2+)-ATPases and reduces the accumulation of Ca(2+) in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis. [provided by RefSeq, Jul 2008]

Forensic Context

A study in pigs demonstrated that the SLN is a mediator of sarcoplasmic reticulum calcium ATPase (SERCA) uncoupling in skeletal muscle non-shivering thermogenesis, though its specific role in large mammals is considered controversial [Yang et al. DOI:10.3390/ijms24087431].