Basic Information

Symbol
SLPI
RNA class
mRNA
Alias
Secretory Leukocyte Peptidase Inhibitor WFDC4 BLPI WAP4 ALP Antileukoproteinase HUSI-I ALK1 HUSI Secretory Leukocyte Protease Inhibitor (Antileukoproteinase) WAP Four-Disulfide Core Domain Protein 4 Seminal Proteinase Inhibitor Mucus Proteinase Inhibitor Protease Inhibitor WAP4 HUSI-1 MPI Secretory Leukocyte Protease Inhibitor
Location (GRCh38)
20:45252239-45254564
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003064.4
Sequence length
596.0 nt
GC content
0.5218

Transcripts

ID Sequence Length GC content
NM_003064.4 NCBI
AGAGUCACUCCUGCCUUCACCAUGAAGUCCAGCGGCCUCUUCCCCUUCC… 596 nt 0.5218
Summary

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]

Forensic Context

A study in mice demonstrated that the SLPI mRNA and protein levels were significantly elevated in lung tissue and plasma in a cecal ligation and puncture model of sepsis-induced acute lung injury [Fang et al. DOI:10.1155/ijog/5684300].