Basic Information

Symbol
SMAD3
RNA class
mRNA
Alias
SMAD Family Member 3 JV15-2 HsT17436 MADH3 Mothers Against Decapentaplegic Homolog 3 Mothers Against DPP Homolog 3 MAD Homolog 3 HMAD-3 HSMAD3 Mad3 MAD, Mothers Against Decapentaplegic Homolog 3 (Drosophila) SMAD, Mothers Against DPP Homolog 3 (Drosophila) MAD, Mothers Against Decapentaplegic Homolog 3 SMAD, Mothers Against DPP Homolog 3 SMA- And MAD-Related Protein 3 Mad Protein Homolog Mad Homolog JV15-2 HSPC193 SMAD 3 LDS1C Smad3 LDS3
Location (GRCh38)
15:67063763-67195173
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005902.4
Sequence length
6464.0 nt
GC content
0.5114

Transcripts

ID Sequence Length GC content
NM_001145102.2 NCBI
AGGAUGACAGAGGAGCCUGCUGCUGAGUUCACUGGUGCUGGGGUUAGGU… 5948 nt 0.4877
NM_001145103.2 NCBI
ACAAACAUGUCUUGCCUGCACCCUAGGCAAACGUGGAAAGGCGCAGCUC… 5785 nt 0.4849
NM_001145104.2 NCBI
AGAUCCUUUGCGGGUAGCCCUGGCGUCCCGCGGAGACCCCACCCCCUGG… 5412 nt 0.4788
NM_001407011.1 NCBI
GAAACACAGACUGGGAGCGGGCGGGAGCGGGAGCGCGGCGCACGCCCCG… 6575 nt 0.5127
NM_001407012.1 NCBI
GAAACACAGACUGGGAGCGGGCGGGAGCGGGAGCGCGGCGCACGCCCCG… 6332 nt 0.5099
NM_001407013.1 NCBI
GAAACACAGACUGGGAGCGGGCGGGAGCGGGAGCGCGGCGCACGCCCCG… 6326 nt 0.5096
NM_001407014.1 NCBI
AAAACAAGCUUCGGGAGUUGGGAGAGAACUGUCCACAGGACACUUGGGG… 6051 nt 0.4900
NM_001407015.1 NCBI
AGGAUGACAGAGGAGCCUGCUGCUGAGUUCACUGGUGCUGGGGUUAGGU… 5816 nt 0.4856
NM_001407016.1 NCBI
ACAAACAUGUCUUGCCUGCACCCUAGGCAAACGUGGAAAGGCGCAGCUC… 6207 nt 0.4923
NM_001407017.1 NCBI
ACACAUUUCAGACUUGGGAGUUGAUCCGGUCCUGCGUGAGCAAAGGCAG… 5540 nt 0.4794
Showing 1 to 10 of 11 entries
Summary

The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, May 2022] CIViC Summary for SMAD3 Gene

Forensic Context

A study in mice demonstrated that ethanol administration significantly upregulated the SMAD3 mRNA and protein expression, which was reversed by astaxanthin (AST) supplement [Liu et al. DOI:10.3390/Md17030181].