Basic Information

Symbol
SMAD7
RNA class
mRNA
Alias
SMAD Family Member 7 MADH7 MADH8 Mothers Against Decapentaplegic Homolog 7 Mothers Against DPP Homolog 8 MAD Homolog 8 HSMAD7 MAD, Mothers Against Decapentaplegic Homolog 7 (Drosophila) MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 7 Mothers Against Decapentaplegic, Drosophila, Homolog Of, 7 SMAD, Mothers Against DPP Homolog 7 (Drosophila) Mothers Against Decapentaplegic Homolog 8 SMAD, Mothers Against DPP Homolog 7 Mothers Against DPP Homolog 7 MAD Homolog 7 SMAD 7 CRCS3 Smad7
Location (GRCh38)
18:48919853-48952020
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005904.4
Sequence length
3341.0 nt
GC content
0.5705

Transcripts

ID Sequence Length GC content
NM_001190821.2 NCBI
AUUGCCUGCUUCUCCCCACCCCCAAAUUAAGUUGCUUAGCAAGGGGGAA… 3338 nt 0.5704
NM_001190822.2 NCBI
AGUAAAUACGGAGAAUCACGUCGAACACCAGUGGCCCAGAUACUGUCGU… 2292 nt 0.4965
NM_001190823.2 NCBI
AGUCUCAUUGAGCCUGACUCGAGUAAUGAUUAACUGGCUGCCCGGAGCC… 2385 nt 0.4901
NM_005904.4 NCBI
AUUGCCUGCUUCUCCCCACCCCCAAAUUAAGUUGCUUAGCAAGGGGGAA… 3341 nt 0.5705
Summary

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Forensic Context

A study in mice demonstrated that the SMAD7 is a target of exosomal miR-21-5p, where its suppression by this miRNA delivered from traumatic brain injury patient-derived exosomes promotes osteogenic differentiation of human mesenchymal stem cells and enhances fracture healing in a femoral fracture model [Lin et al. DOI:10.1038/s12276-023-00956-8]. In a rat model of radiation-induced lung injury, the SMAD7 was identified as a predicted and validated target gene of miR-21, with its expression being negatively correlated with miR-21 and inhibited by miR-21 mimic transfection in rat lung type II pneumocyte cells [Xie et al. DOI:10.1186/1748-717X-9-111].