Basic Information

Symbol
SMARCD3
RNA class
mRNA
Alias
SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3 BAF60C CRACD3 Rsc6p SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 3 SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily D Member 3 Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60C 60 KDa BRG-1/Brm-Associated Factor Subunit C SWI/SNF Complex 60 KDa Subunit C BRG1-Associated Factor 60C Swp73-Like Protein 60kDa BRG-1/Brm Associated Factor Subunit C Chromatin Remodeling Complex BAF60C Subunit
Location (GRCh38)
7:151238764-151277896
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001003801.2
Sequence length
1907.0 nt
GC content
0.5826

Transcripts

ID Sequence Length GC content
NM_001003801.2 NCBI
ACUCCGCUCGAGUAGAAGUGUGAGAGAGCCCAGCAGGACUCAGAGGGGA… 1907 nt 0.5826
NM_001003802.2 NCBI
CUGGCAUCUUCCUCCCCUCCUCCUUUCCAGAUCCUCAGAAUGGCCCUUG… 1865 nt 0.5909
NM_003078.4 NCBI
AGGCGCCGGGCCGAGCCGAGCGCCGAGCAGGGAGCGGGCGGCCGCGCUC… 1908 nt 0.6012
Summary

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified SMARCD3 as a gene highly expressed in the sepsis group compared to normal controls through RNA sequencing analysis of peripheral blood samples [Leng et al. DOI:10.2147/IDR.S554915].