Basic Information

Symbol
SMCO1
RNA class
mRNA
Alias
Single-Pass Membrane Protein With Coiled-Coil Domains 1 C3orf43 Single-Pass Membrane And Coiled-Coil Domain-Containing Protein 1 DKFZp313B0440 FLJ41923 Chromosome 3 Open Reading Frame 43
Location (GRCh38)
3:196506878-196515347
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl UniProt GTEx

MANE select

Transcript ID
NM_001077657.3
Sequence length
1790.0 nt
GC content
0.4190

Transcripts

ID Sequence Length GC content
NM_001077657.3 NCBI
AGGCAGAAUGUAGACUGAGCGCUCCUGCUACUGCUGCCUGUUGCUGAGA… 1790 nt 0.4190
NM_001320473.2 NCBI
AGGCAGAAUGUAGACUGAGCGCUCCUGCUACUGCUGCCUGUUGCUGAGA… 1846 nt 0.4231
Summary

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human postmortem prefrontal cortex identified gene modules associated with schizophrenia symptoms, where the SMCO1 was included in the blue gene module, which is located in the 3q29 deletion region and whose expression was significantly correlated with general psychopathology scores and a polygenic risk score for schizophrenia [Miyahara et al. DOI:10.1038/S41398-023-02449-8].