Basic Information

Symbol
SMG1
RNA class
mRNA
Alias
SMG1 Nonsense Mediated MRNA Decay Associated PI3K Related Kinase LIP ATX KIAA0421 Nonsense Mediated MRNA Decay-Associated PI3K-Related Kinase SMG1 SMG1 Phosphatidylinositol 3-Kinase-Related Kinase Lambda/Iota Protein Kinase C-Interacting Protein Serine/Threonine-Protein Kinase SMG1 Lambda-Interacting Protein EC 2.7.11.1 Smg-1 Homolog, Phosphatidylinositol 3-Kinase-Related Kinase (C. Elegans) SMG1, Nonsense Mediated MRNA Decay Associated PI3K Related Kinase Smg-1 Homolog, Phosphatidylinositol 3-Kinase-Related Kinase Phosphatidylinositol 3-Kinase-Related Kinase PI-3-Kinase-Related Kinase SMG-1 EC 2.7.11 61E3.4 HSMG-1 SMG-1
Location (GRCh38)
16:18804860-18926412
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015092.5
Sequence length
16062.0 nt
GC content
0.4308

Transcripts

ID Sequence Length GC content
NM_015092.5 NCBI
AGUGGCCGUGUGAGCGUGAGGAGCUGCCGCCACCGCCUGCUCCUCGUCG… 16062 nt 0.4308
Summary

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternatively spliced transcript variants have been described, but their full-length nature has yet to be determined. [provided by RefSeq, Mar 2013]

Forensic Context

A study in humans demonstrated that the SMG1 mRNA was down-regulated by 26% in pericontusional brain tissue from a patient with traumatic brain injury (patient T3) compared to control tissue, as identified through cDNA microarray analysis [Michael et al. DOI:10.1016/j.jocn.2004.11.003].