Basic Information

Symbol
SMG7
RNA class
mRNA
Alias
SMG7 Nonsense Mediated MRNA Decay Factor EST1C KIAA0250 C1orf16 SGA56M Nonsense-Mediated MRNA Decay Factor SMG7 SMG-7 Smg-7 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans) EST1 Telomerase Component Homolog C (S. Cerevisiae) Smg-7 Homolog, Nonsense Mediated MRNA Decay Factor SMG7, Nonsense Mediated MRNA Decay Factor Breast Cancer-Associated Antigen SGA-56M EST1 Telomerase Component Homolog C Chromosome 1 Open Reading Frame 16 Ever Shorter Telomeres 1C EST1-Like Protein C SMG-7 Homolog HSMG-7
Location (GRCh38)
1:183471957-183598246
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001375584.1
Sequence length
5946.0 nt
GC content
0.4847

Transcripts

ID Sequence Length GC content
NM_001394146.1 NCBI
GAGGAGCCGGAGGAGAGGAAGAUGGCGGCGGCCGCCAGCACCCGCGGUG… 5836 nt 0.4824
NM_001394147.1 NCBI
GAGGAGCCGGAGGAGAGGAAGAUGGCGGCGGCCGCCAGCACCCGCGGUG… 5626 nt 0.4845
NM_173156.3 NCBI
GAGGAGCCGGAGGAGAGGAAGAUGGCGGCGGCCGCCAGCACCCGCGGUG… 5796 nt 0.4829
NM_201568.3 NCBI
GAGGAGCCGGAGGAGAGGAAGAUGGCGGCGGCCGCCAGCACCCGCGGUG… 5658 nt 0.4850
NM_201569.3 NCBI
GAGGAGCCGGAGGAGAGGAAGAUGGCGGCGGCCGCCAGCACCCGCGGUG… 4649 nt 0.4859
Showing 21 to 25 of 25 entries
Summary

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

Forensic Context

No relevant information is available at the moment.