Basic Information

Symbol
SMO
RNA class
mRNA
Alias
Smoothened, Frizzled Class Receptor FZD11 SMOH Smoothened, Seven Transmembrane Spanning Receptor Smoothened, Frizzled Family Receptor Frizzled Family Member 11 Protein Smoothened Protein Gx Seven Transmembrane Helix Receptor Smoothened (Drosophila) Homolog Smoothened Homolog (Drosophila) Smoothened Homolog CRJS PHLS Gx
Location (GRCh38)
7:129188511-129213546
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005631.5
Sequence length
3977.0 nt
GC content
0.6218

Transcripts

ID Sequence Length GC content
NM_005631.5 NCBI
AUUCCAGAGAGCCCAGCGAGCUAGAGCAACAAAGGAGCCGGGUCGCCGG… 3977 nt 0.6218
Summary

The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010] CIViC Summary for SMO Gene

Forensic Context

A study in mice and human RWPE-1 cells demonstrated that cadmium exposure induced prostatic fibrosis, epithelial-mesenchymal transition, and primary ciliogenesis, which was associated with increased expression of the SMO as a marker of the activated SHH signaling pathway [Huang et al. DOI:10.1002/Jat.4436].