Basic Information

Symbol
SMOX
RNA class
mRNA
Alias
Spermine Oxidase PAOh1 SMO C20orf16 PAO Polyamine Oxidase 1 DJ779E11.1 FLJ20746 MGC1010 PAO-1 Putative Cyclin G1 Interacting Protein Chromosome 20 Open Reading Frame 16 Flavin-Containing Spermine Oxidase Flavin Containing Amine Oxidase EC 1.5.3.16 PAO1 PAOH
Location (GRCh38)
20:4120980-4187748
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_175839.3
Sequence length
2164.0 nt
GC content
0.6072

Transcripts

ID Sequence Length GC content
NM_001270691.2 NCBI
ACACAGGCCGCGGCGGCUGGCUCGGGCCCCUACGGUCCCGGCGGCGGCU… 2254 nt 0.6056
NM_175839.3 NCBI
ACACAGGCCGCGGCGGCUGGCUCGGGCCCCUACGGUCCCGGCGGCGGCU… 2164 nt 0.6072
NM_175840.3 NCBI
ACACAGGCCGCGGCGGCUGGCUCGGGCCCCUACGGUCCCGGCGGCGGCU… 2005 nt 0.6035
NM_175841.3 NCBI
ACACAGGCCGCGGCGGCUGGCUCGGGCCCCUACGGUCCCGGCGGCGGCU… 1069 nt 0.6006
NM_175842.3 NCBI
ACACAGGCCGCGGCGGCUGGCUCGGGCCCCUACGGUCCCGGCGGCGGCU… 2095 nt 0.6019
Summary

Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]

Forensic Context

A study in humans demonstrated that the SMOX mRNA was significantly down-regulated in the post-mortem prefrontal cortex of depressed suicide completers compared to psychiatrically healthy controls [Lopez et al. DOI:10.1017/S1461145713000941].