Basic Information

Symbol
SMPD3
RNA class
mRNA
Alias
Sphingomyelin Phosphodiesterase 3 Neutral Sphingomyelinase II NSMASE2 Neutral Sphingomyelinase 2 NSMase-2 Sphingomyelin Phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II) EC 3.1.4.12 NSMase2
Location (GRCh38)
16:68358327-68448508
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_018667.4
Sequence length
5271.0 nt
GC content
0.6080

Transcripts

ID Sequence Length GC content
NM_018667.4 NCBI
GUGCUGAGUCUGAGGGAGGCUCCGGACCCGAGAGCCGCGAGAGCCGCCG… 5271 nt 0.6080
Summary

Enables sphingomyelin phosphodiesterase activity. Involved in sphingomyelin catabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Biomarker of pulmonary emphysema. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human patients identified SMPD3 as a mechanistically relevant mRNA that was upregulated in blood samples from myocardial fibrosis patients compared to those with acute myocardial infarction [Wang et al. DOI:10.3389/fcvm.2021.664044].