Basic Information

Symbol
SMURF2
RNA class
mRNA
Alias
SMAD Specific E3 Ubiquitin Protein Ligase 2 HECT-Type E3 Ubiquitin Transferase SMURF2 SMAD Ubiquitination Regulatory Factor 2 E3 Ubiquitin-Protein Ligase SMURF2 HSMURF2 SMAD-Specific E3 Ubiquitin-Protein Ligase 2 E3 Ubiquitin Ligase SMURF2 EC 2.3.2.26 EC 6.3.2
Location (GRCh38)
17:64542282-64662335
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022739.4
Sequence length
6240.0 nt
GC content
0.4175

Transcripts

ID Sequence Length GC content
NM_022739.4 NCBI
AGACAAGAGGGCGGGUGGAGGAGGAAGCGGCCGAGCCCAGAGUUCUGCU… 6240 nt 0.4175
Summary

Enables SMAD binding activity; identical protein binding activity; and ubiquitin protein ligase activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Located in nuclear speck. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the SMURF2 in microglia, which is a component of the ubiquitin-mediated proteolysis pathway [Oladapo et al. DOI:10.3390/Ijms26020649].