Basic Information

Symbol
SNCA
RNA class
mRNA
Alias
Synuclein Alpha NACP Alpha-Synuclein PARK1 PD1 Synuclein, Alpha (Non A4 Component Of Amyloid Precursor) PARK4 Parkinson Disease (Autosomal Dominant, Lewy Body) 4 Non A4 Component Of Amyloid Precursor Non-A4 Component Of Amyloid Precursor Non A-Beta Component Of AD Amyloid Non-A Beta Component Of AD Amyloid Synuclein Alpha-140 I+/--Synuclein Α-Synuclein
Location (GRCh38)
4:89700345-89838315
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000345.4
Sequence length
3177.0 nt
GC content
0.3812

Transcripts

ID Sequence Length GC content
NM_000345.4 NCBI
GGCGACGACCAGAAGGGGCCCAAGAGAGGGGGCGAGCGACCGAGCGCCG… 3177 nt 0.3812
NM_001146054.2 NCBI
GGCGACGACCAGAAGGGGCCCAAGAGAGGGGGCGAGCGACCGAGCGCCG… 3396 nt 0.3919
NM_001146055.2 NCBI
GCUUCUCCAUUCUGGUGUGAUCCAGGAACAGCUGUCUUCCAGCUCUGAA… 3030 nt 0.3620
NM_001375285.1 NCBI
GCUUCUCCAUUCUGGUGUGAUCCAGGAACAGCUGUCUUCCAGCUCUGAA… 3099 nt 0.3675
NM_001375286.1 NCBI
GGCGACGACCAGAAGGGGCCCAAGAGAGGGGGCGAGCGACCGAGCGCCG… 3041 nt 0.3673
NM_001375287.1 NCBI
GGCGACGACCAGAAGGGGCCCAAGAGAGGGGGCGAGCGACCGAGCGCCG… 3465 nt 0.3962
NM_001375288.1 NCBI
GAGUGUGAGCGGCGCCUGCUCAGGGUAGAUAGCUGAGGGCGGGGGUGGA… 3091 nt 0.3675
NM_001375290.1 NCBI
GCUCUAAUUCUCUGCACCUUCUCAAGCAUUGUGCAGAUUGGUUUUCUGG… 2984 nt 0.3515
NM_007308.3 NCBI
GGCGACGACCAGAAGGGGCCCAAGAGAGGGGGCGAGCGACCGAGCGCCG… 3312 nt 0.3901
Summary

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

Forensic Context

No relevant information is available at the moment.