Basic Information

Symbol
SND1
RNA class
mRNA
Alias
Staphylococcal Nuclease And Tudor Domain Containing 1 TDRD11 P100 TSN Staphylococcal Nuclease Domain-Containing Protein 1 Tudor Domain-Containing Protein 11 EBNA2 Coactivator P100 Tudor-SN Testis Tissue Sperm-Binding Protein Li 82P P100 EBNA2 Co-Activator 100 KDa Coactivator P100 Co-Activator EC 3.1.31.1
Location (GRCh38)
7:127652145-128092609
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014390.4
Sequence length
3448.0 nt
GC content
0.5452

Transcripts

ID Sequence Length GC content
NM_014390.4 NCBI
CUCUUUCGCUCCGUGUCCCGCUGCUGCUCCUGUGAGCGCCCGGCGAGUC… 3448 nt 0.5452
Summary

This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

Forensic Context

A study in mice and rats demonstrated that the SND1 was identified as a downregulated same-trend differentially expressed gene in the corpus cavernosum of animals with age-related erectile dysfunction, where multi-omics analyses revealed conserved molecular mechanisms involving downregulation of mitochondrial activity and disruption of protein homeostasis [Long et al. DOI:10.1093/sexmed/qfaf078].