Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome and regulation of RNA splicing. Located in nucleoplasm. Part of U1 snRNP and spliceosomal complex. Implicated in disease of mental health and systemic lupus erythematosus. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in humans demonstrated that the SNRNP70 was identified as a housekeeping gene in the Information class and was differentially expressed between a specific male monozygotic twin pair, belonging to the least variable category of expression variation [Sharma et al. DOI:10.1152/physiolgenomics.00228.2003].