Basic Information

Symbol
SNW1
RNA class
mRNA
Alias
SNW Domain Containing 1 SKIP NCoA-62 PRPF45 Prp45 SKIP1 FUN20 SKIIP Bx42 Nuclear Receptor Coactivator NCoA-62 SNW Domain-Containing Protein 1 SKI Interacting Protein Ski-Interacting Protein Nuclear Protein SkiP Nuclear Receptor Coactivator, 62-KD Homolog Of Drosophila BX42
Location (GRCh38)
14:77717599-77761207
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012245.3
Sequence length
2129.0 nt
GC content
0.4462

Transcripts

ID Sequence Length GC content
NM_001318844.2 NCBI
GUCGCUCGCGCUGGAAGAAGCGGAAGAAGAUGGCGCUCACCAGCUUUUU… 2209 nt 0.4436
NM_012245.3 NCBI
GUCGCUCGCGCUGGAAGAAGCGGAAGAAGAUGGCGCUCACCAGCUUUUU… 2129 nt 0.4462
Summary

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Forensic Context

No relevant information is available at the moment.