Basic Information
MANE select
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| CUUUCUCUAGACGCGUCUUGCUGGGAGAGUGUCCGUUGCUUCCCGUCCG… | 2016 nt | 0.4167 | |
| CUUUCUCUAGACGCGUCUUGCUGGGAGAGUGUCCGUUGCUUCCCGUCCG… | 2341 nt | 0.4635 | |
| CUUUCUCUAGACGCGUCUUGCUGGGAGAGUGUCCGUUGCUUCCCGUCCG… | 2099 nt | 0.4288 |
Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein functions in endosomal sorting, the phosphoinositide-signaling pathway, and macropinocytosis. This gene may play a role in the tumorigenesis of papillary thyroid carcinoma. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Forensic Context
A study in mice demonstrated that the SNX5 mRNA was down-regulated (0.15-fold) in bone marrow cells 6 hours after 6.5 Gy whole-body ionizing radiation, as identified by microarray analysis [Dai et al. DOI:10.1080/09553000600857389].