Basic Information

Symbol
SOAT1
RNA class
mRNA
Alias
Sterol O-Acyltransferase 1 ACAT1 ACAT SOAT STAT Sterol O-Acyltransferase (Acyl-Coenzyme A: Cholesterol Acyltransferase) 1 Acyl-Coenzyme A:Cholesterol Acyltransferase 1 EC 2.3.1.26 ACAT-1 ACACT Acyl-Coenzyme A: Cholesterol Acyltransferase Cholesterol Acyltransferase 1 ACACT1
Location (GRCh38)
1:179293440-179358680
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003101.6
Sequence length
6840.0 nt
GC content
0.3953

Transcripts

ID Sequence Length GC content
NM_001252511.2 NCBI
GCUUUAGCUUAGCAGGCGACGUUGCGGGCCCUGGGCGCCAGGAGAGCUU… 6781 nt 0.3954
NM_001252512.2 NCBI
GCUUUAGCUUAGCAGGCGACGUUGCGGGCCCUGGGCGCCAGGAGAGCUU… 6714 nt 0.3941
NM_003101.6 NCBI
GCUUUAGCUUAGCAGGCGACGUUGCGGGCCCUGGGCGCCAGGAGAGCUU… 6840 nt 0.3953
Summary

The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Forensic Context

A study in humans demonstrated that the mRNA of the SOAT1 was significantly upregulated in salivary extracellular vesicles from emergency department patients with acute head trauma compared to healthy controls (p=0.044) and also showed a significant difference in expression between these acute patients and those from an outpatient concussion clinic (p=0.0481) [Cheng et al. DOI:10.1002/jcp.28139].